| Pair Name | Osthol, Lobaplatin | ||
| Phytochemical Name | Osthol (PubChem CID: 10228 ) | ||
| Anticancer drug Name | Lobaplatin (PubChem CID: 24202037 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Osthol, Lobaplatin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | CASP3 | hsa836 | |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | OST enhanced the apoptosis-mediated growth inhibitory effect of lobaplatin on breast cancer cells and has potential for the treatment of breast cancer in the future. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells. Med Oncol. 2021 Nov 27;39(1):16. doi: 10.1007/s12032-021-01609-4. | Click |
